The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3′-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassayguided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC50 0.53–0.60 mM.

Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity / Benamar, Houari; Tomassini, Lamberto; Venditti, Alessandro; Marouf, Abderrazak; Bennaceur, Malika; Nicoletti, Marcello. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 30:22(2016), pp. 2567-2574. [10.1080/14786419.2015.1131984]

Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity

TOMASSINI, Lamberto;VENDITTI, ALESSANDRO;NICOLETTI, Marcello
2016

Abstract

The whole plant ethanolic extract of Solenanthus lanatus was used for the isolation of acetylcholinesterase inhibitors. A new pyrrolizidine alkaloid, 7-O-angeloylechinatine N-oxide, 1, was isolated together with three known compounds of the same class (3′-O-acetylheliosupine N-oxide, 2, heliosupine N-oxide, 3, and heliosupine, 4), by bioassayguided approach. Their structures were elucidated by spectroscopic methods. All the isolated compounds showed inhibition activity against the AChE, with IC50 0.53–0.60 mM.
2016
7-O-angeloylechinatine N-oxide; anti-AChE activity; boraginaceae; pyrrolizidine alkaloids; solenantus lanatus; plant science; biochemistry; analytical chemistry; organic chemistry
01 Pubblicazione su rivista::01a Articolo in rivista
Pyrrolizidine alkaloids from Solenanthus lanatus DC. with acetylcholinesterase inhibitory activity / Benamar, Houari; Tomassini, Lamberto; Venditti, Alessandro; Marouf, Abderrazak; Bennaceur, Malika; Nicoletti, Marcello. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - STAMPA. - 30:22(2016), pp. 2567-2574. [10.1080/14786419.2015.1131984]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/886077
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